CerTest Lactoferrin one step card test is a coloured chromatographic immunoassay for the semi-quantitative detection of human lactoferrin (hLf) in stool samples that may reflect intestinal inflammation caused by several pathologies (inflammatory bowel disease, colorectal cancer and some enteropathies).
CerTest Lactoferrin card test offers a simple, a highly sensitivity and non-invasive screening assay to determine intestinal inflammatory activity, to monitor treatment response in these patients and to predict risk of relapse.
Lactoferrin is a glycoprotein component of neutrophil secondary granules, a primary component of the acute inflammatory response and is released from fecal leukocytes.
This protein is resistant to proteolysis in the faeces and may serve as a marker of inflammation in the intestine.
The major cause of fecal neutrophils in patients with chronic diarrhoea is chronic inflammatory bowel disease of the colon (i.e., Crohn’s Disease and ulcerative colitis). Lactoferrin has been also studied as a predictor of infection with invasive enteropathogens in children with diarrhoea.
Bacterial inflammatory diarrhea may be caused by Shigella, Salmonella, Campylobacter and Clostridium difficile.