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Recombinant proteins for SARS-CoV-2 detection

25/06/2020|

Recombinant proteins for SARS-CoV-2 detection

Coronavirus are enveloped non-segmented positive-sense RNA viruses and belong to Coronaviridae family. In December 2019, some people from Wuhan, Hubei Province, China, presented pneumonia of unknown cause. Deep sequencing analysis of the respiratory samples indicated a novel coronavirus, which was named firstly 2019 novel coronavirus (2019-nCoV) and lately SARS-CoV-2.

Based on all available information, complete Spike Glycoprotein (S), expressed in mammalian cells, and Nucleoprotein (N) are the best antigens for the development of a serology test.

The complete extracellular form of the Spike Glycoprotein (S) (MT-25C19S), which comprises the S1 and S2 domains in trimeric conformation, has been shown to provide greater sensitivity than the use of the S1 domain alone, without losing specificity and is a perfect antigen for Rapid Test, ELISA or CLIA manufacturing.

SARS-CoV-2 detection:

Mammalian expression

Bacterial expression

Antigens from other Coronavirus

CerTest bioSCIENCE develops and offers liquid recombinant proteins with high purity and stability, through a process of cloning, expresión, multi-step purification and buffer optimization.

 

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