CerTest FOB Turbilatex is a latex turbidimetric assay for the quantitative detection of haemoglobin in human stool samples. This assay is simple, widely applicable and test results are obtained in a very short time.
The intended use of the test is to make a presumptive diagnosis of faecal occult blood (gastrointestinal bleeding).
Colorectal cancer is the second leading cause of illness and death in Western world. The screening with faecal occult blood tests is based on the concept that important colonic neoplasm, such us early-stage cancer and large adenomatous polyps, will bleed, for which may be detected by an occult blood test. Colorectal cancer is also associated with local acute inflammatory reaction being visualized, in some cases, by white cell neutrophil scanning.
Haemoglobin is the iron-containing oxygen-transport in the blood cells of all vertebrates that may be leaked into gastrointestinal tract and then discharged with the feces in gastrointestinal bleeding diseases.
When gastrointestinal blood is lost, the stool will contain a combination of intact or nearly intact haemoglobin, intact heme and heme-derived porphyrins an amounts that depend on the site and amount of bleeding and the transit time through the gut.
The screening of Faecal Occult Blood tests (FOB) are applied to early diagnose colonic neoplasma, such as early-state cancer and large adenomatous polyps.