Clostridium difficile Toxin A/B

Clostridium difficile (CD) is an anaerobic, Gram-positive, spore-forming bacterium and the leading cause of antibiotic-associated diarrhoea and one of the main causes of healthcare-associated infectious diarrhoea. Infection usually develops after disruption of the normal intestinal microbiota, most commonly following antibiotic treatment, allowing toxigenic strains to proliferate and produce Toxins A and B, the main virulence factors responsible for intestinal damage.

Clinical manifestations range from mild watery diarrhoea to pseudomembranous colitis, toxic megacolon and, in severe cases, death. Hospitalized patients, older adults, individuals receiving broad-spectrum antibiotics and immunocompromised patients are at increased risk of developing severe disease.

CerTest CLIA Clostridium difficile Toxin A/B Ag detects Clostridium difficile Toxin A and/or Toxin B antigens in human stool samples, providing a reliable aid in the diagnosis of toxigenic C. difficile infectio