FOB

Colorectal cancer is a leading cause of illness and death in Western world. Screening with
fecal occult blood tests is based on the concept that important target colonic neoplasm, such as early-stage cancer and large adenomatous polyps, bleed and may be detected by an occult blood test. When gastrointestinal blood is lost, the stool contains a combination of intact or nearly intact hemoglobin, intact heme, and heme-derived porphyrins in amounts that depend on the site and amount of bleeding and the transit time through the gut. Immunochemical tests detect intact or nearly intact human hemoglobin, being a very specific technique for detecting loss of blood from the lower intestine, because blood from lower sites is less degraded during transit.

The CerTest FOB Blister Test is a qualitative immunochromatographic assay for the determination of human hemoglobin in stool samples.

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